Tissue loading diagram

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Tissue loading diagram

Postby DiveDiva » Wed Jan 21, 2009 10:47 am

Shamelessly stolen from another board (thanks scubaboard!) but for its brilliance :wink: this is a diagram showing theoretical loading relative to different tissues and typical areas they occur in the body. "Fast" tissues at the top (Brain and CNS) and "slowest" tissue (bone) at the bottom. Just thought it was interesting, like!

Image
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Re: Tissue loading diagram

Postby Cameron_R » Wed Jan 21, 2009 11:57 am

Very cool. :o thanks :)

What are the % numbers on the right heart arrows coming out of the organs? and
What are the numbers below each organ?
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Re: Tissue loading diagram

Postby Jason » Wed Jan 21, 2009 12:24 pm

Yes DD, do tell. :)
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Re: Tissue loading diagram

Postby Andy » Wed Jan 21, 2009 2:08 pm

The diagram is giving relative blood flows in a "typical" person.

A typical heart pumps 5 L/min, which splits into various amounts based on different tissues. A brain, then, typical has a blood flow of 0.7 L/min.

The numbers under each type of tissue correspond to the number of mL of blood per 100g of tissue in a minute.

So, if the brain gets 700 mL per minute, we can work out the "average" mass of a human brain from the data as being about 1.3kg (check my maths!) by (700 * 100) / 55 * 1000. Checking on Wikipedia, a typical human brain weighs 1300-1400g.
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Re: Tissue loading diagram

Postby Jason » Wed Jan 21, 2009 5:28 pm

Thanks Andy :)
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Re: Tissue loading diagram

Postby DiveDiva » Wed Jan 21, 2009 5:52 pm

Andy wrote:The diagram is giving relative blood flows in a "typical" person.

A typical heart pumps 5 L/min, which splits into various amounts based on different tissues. A brain, then, typical has a blood flow of 0.7 L/min.

The numbers under each type of tissue correspond to the number of mL of blood per 100g of tissue in a minute.

So, if the brain gets 700 mL per minute, we can work out the "average" mass of a human brain from the data as being about 1.3kg (check my maths!) by (700 * 100) / 55 * 1000. Checking on Wikipedia, a typical human brain weighs 1300-1400g.


Ya beat me to it :wink:

So the average total blood flow is 5L/min and of that, 0.7 L/min (or 14% of total) goes to the brain and 55 mL/100 g/min is the amount of blood per unit mass of brain.

Have a looks at: http://rubicon-foundation.org/ and http://archive.rubicon-foundation.org/. These are awesome resources, full of information about research projects relating to diving physiology and some relevant published data.
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Thanks!!

Postby Gene_Hobbs » Thu Jan 22, 2009 4:46 am

DiveDiva wrote:Have a looks at: http://rubicon-foundation.org/ and http://archive.rubicon-foundation.org/. These are awesome resources, full of information about research projects relating to diving physiology and some relevant published data.


Thanks for the plug! :D We are working hard to get a few more cool collections started this year as well.
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Re: Tissue loading diagram

Postby Andy » Thu Jan 22, 2009 10:36 am

The more interesting question is how blood flow etc actually relates to the theoretical decompression models in terms of nitrogen loading.... :D
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Re: Tissue loading diagram

Postby Dr Simon Mitchell » Sun Jan 25, 2009 8:59 pm

Andy wrote:The more interesting question is how blood flow etc actually relates to the theoretical decompression models in terms of nitrogen loading.... :D


Hello Andy,

Blood flow (perfusion) is one of a number of variables that may be applicable to modelling the uptake and elimination of an inert gas from a tissue. The candidates and their effects (in general terms) are:

Perfusion: more (per unit weight of tissue) = faster uptake and outgassing
Pgas difference between blood and tissue: the greater the difference the faster the gas movement
Diffusivity of the gas: the more diffusible, the faster the gas movement
Solubility of the gas: the more soluble, the faster the gas movement
The area of the diffusion barrier (contact area between one tissue and another): greater contact = faster movement
The diffusion distance: thicker barrier may = slower movement

Not all gas flux models consider all these parameters, but complex ones may do, like our model of the inner ear.
Its a messy and imprecise business!!

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Re: Tissue loading diagram

Postby Jason » Sun Jan 25, 2009 10:59 pm

I can see why some old time divers (retired) tell me their bones are all like Pumice - especially the ones who had to earn a living beyond safe limits.
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Re: Tissue loading diagram

Postby DiveDiva » Mon Jan 26, 2009 10:27 am

Vampire Squid wrote:I can see why some old time divers (retired) tell me their bones are all like Pumice - especially the ones who had to earn a living beyond safe limits.


:shock:
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Re: Tissue loading diagram

Postby Andy » Tue Jan 27, 2009 2:13 pm

Thanks, Simon! I've been reading about this of late - thinking about how tissue compartment m-values and half times relate to actual physiological parameters.

Even at a simplistic level, it's not straight forward. I can see how blood flow contributes to both, but was also thinking that the properties of actual tissues are just as important. I find it fascinating (but then, I am a geek).
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Re: Tissue loading diagram

Postby Jason » Wed Jan 28, 2009 9:25 pm

As the band TISM once sang in regards to guys like Glenn ("Oh-ah") McGrath, Shane (Wrong'un) Warne & Adam (The Great) Gilchrist who came to dominate in their profession at the time "...its the nerds with the bad haircuts that give it a real go!". Now I'm not saying that you have a bad haircut ( ...do you have a bad haircut Andy?), nor do you have a fish for a head - but your 'nerdishness' is 10 outta 10. I would dive the Lake any day with you dude!
Just drifting along with whatever is current.
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Re: Tissue loading diagram

Postby Andy » Wed Jan 28, 2009 9:37 pm

Hair is pretty straightforward.... a number 1 buzzcut all over. I should get my eyes checked, though, I think I should be wearing glasses.

Come to the lake, Luke. Feel the power of the lake.....



I just love learning stuff about deco theory. I look at the profiles that some of the more agressive divers do and think "Sh!t, if I did that I'd probably die" and then try and work out why they didn't.
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Re: Tissue loading diagram

Postby Jason » Wed Jan 28, 2009 9:51 pm

The power of the Lake is strong...it is calling me and my dive buddies here know that I must eventually leave these shores and venture across to complete my training.
Just drifting along with whatever is current.
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